ASSISTant

ASSISTant is a package to assist in performing Adaptive Subgroup Selection In Sequential Trials.

Install this package (after taking care of dependencies shown) the usual way in R once it gets on CRAN or via:

require("mvtnorm")
require("R6")
library(devtools)
install_github("bnaras/ASSISTant")

ASSISTant provides a three-stage adaptive group sequential clinical trial design with provision for selecting a subgroup where the treatment may be effective. The package provides facilities for design, exploration and analysis of such trials. A complete implementation of the initial design for the DEFUSE-3 trial is also provided as a vignette.