CFAcoop: Colony Formation Assay: Taking into Account Cellular Cooperation
Cellular cooperation compromises the plating efficiency-based
analysis of clonogenic survival data. This tool provides functions that
enable a robust analysis of colony formation assay (CFA) data in presence
or absence of cellular cooperation.
The implemented method has been described
in Brix et al. (2020). (Brix, N., Samaga, D., Hennel, R. et al.
"The clonogenic assay: robustness of plating efficiency-based analysis is
strongly compromised by cellular cooperation." Radiat Oncol 15, 248 (2020).
Power regression for parameter estimation, calculation of survival
fractions, uncertainty analysis and plotting functions are provided.
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