The **enrichwith** package provides the `enrich`

method to enrich list-like R objects with new, relevant components. The resulting objects preserve their class, so all methods associated with them still apply.

This vignette is a short case study demonstrating how enriched `glm`

objects can be used to implement a *quasi Fisher scoring* procedure for computing reduced-bias estimates in generalized linear models (GLMs). Kosmidis and Firth (2010) describe a parallel quasi Newton-Raphson procedure.

Heinze and Schemper (2002) used a logistic regression model to analyse data from a study on endometrial cancer. Agresti (2015 Section 5.7) provide details on the data set. Below, we fit a probit regression model with the same linear predictor as the logistic regression model in Heinze and Schemper (2002).

```
# Get the data from the online supplmementary material of Agresti (2015)
data("endometrial", package = "enrichwith")
modML <- glm(HG ~ NV + PI + EH, family = binomial("probit"), data = endometrial)
theta_mle <- coef(modML)
summary(modML)
```

```
##
## Call:
## glm(formula = HG ~ NV + PI + EH, family = binomial("probit"),
## data = endometrial)
##
## Deviance Residuals:
## Min 1Q Median 3Q Max
## -1.47007 -0.67917 -0.32978 0.00008 2.74898
##
## Coefficients:
## Estimate Std. Error z value Pr(>|z|)
## (Intercept) 2.18093 0.85732 2.544 0.010963 *
## NV 5.80468 402.23641 0.014 0.988486
## PI -0.01886 0.02360 -0.799 0.424066
## EH -1.52576 0.43308 -3.523 0.000427 ***
## ---
## Signif. codes: 0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
##
## (Dispersion parameter for binomial family taken to be 1)
##
## Null deviance: 104.90 on 78 degrees of freedom
## Residual deviance: 56.47 on 75 degrees of freedom
## AIC: 64.47
##
## Number of Fisher Scoring iterations: 17
```

As is the case for the logistic regression in Heinze and Schemper (2002), the maximum likelihood (ML) estimate of the parameter for `NV`

is actually infinite. The reported, apparently finite value is merely due to false convergence of the iterative estimation procedure. The same is true for the estimated standard error, and, hence the value `r round(coef(summary(modML))["NV", "z value"], 3)`

for the \(z\)-statistic cannot be trusted for inference on the size of the effect for `NV`

.

In categorical-response models like the above, the bias reduction method in Firth (1993) has been found to result in finite estimates even when the ML ones are infinite (see, Heinze and Schemper 2002, for logistic regressions; Kosmidis and Firth 2011, for multinomial regressions; Kosmidis 2014, for cumulative link models).

One of the variants of that bias reduction method is implemented in the **brglm** R package, which estimates binomial-reponse GLMs using iterative ML fits on binomial pseudo-data (see, Kosmidis 2007, Chapter 5, for details). The reduced-bias estimates for the probit regression on the endometrial data can be computed as follows.

`## Loading required package: profileModel`

`## 'brglm' will gradually be superseded by 'brglm2' (https://cran.r-project.org/package=brglm2), which provides utilities for mean and median bias reduction for all GLMs and methods for the detection of infinite estimates in binomial-response models.`

```
modBR <- brglm(HG ~ NV + PI + EH, family = binomial("probit"), data = endometrial)
theta_brglm <- coef(modBR)
summary(modBR)
```

```
##
## Call:
## brglm(formula = HG ~ NV + PI + EH, family = binomial("probit"),
## data = endometrial)
##
##
## Coefficients:
## Estimate Std. Error z value Pr(>|z|)
## (Intercept) 1.91460 0.78877 2.427 0.015210 *
## NV 1.65892 0.74730 2.220 0.026427 *
## PI -0.01520 0.02089 -0.728 0.466793
## EH -1.37988 0.40329 -3.422 0.000623 ***
## ---
## Signif. codes: 0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
##
## (Dispersion parameter for binomial family taken to be 1)
##
## Null deviance: 93.983 on 78 degrees of freedom
## Residual deviance: 57.587 on 75 degrees of freedom
## AIC: 65.587
```

The \(z\)-statistic for `NV`

has value 2.22 when based on the reduced-bias estimates, providing some evidence for the existence of an effect.

In the following, we use **enrichwith** to implement two variants of the bias reduction method via a unifying quasi Fisher scoring estimation procedure.

Consider a parametric statistical model \(\mathcal{P}_\theta\) with unknown parameter \(\theta \in \Re^p\) and the iteration \[\theta^{(k + 1)} := \theta^{(k)} + \left\{i(\theta^{(k)})\right\}^{-1} s(\theta^{(k)}) - c(\theta^{(k)}) b(\theta^{(k)})\] where \(\theta^{(k)}\) is the value of \(\theta\) at the \(k\)th iteration, \(s(\theta)\) is the gradient of the log-likelihood for \(\mathcal{P}_\theta\), \(i(\theta)\) is the expected information matrix, and \(b(\theta)\) is the \(O(n^{-1})\) term in the expansion of the bias of the ML estimator of \(\theta\) (see, for example, Cox and Snell 1968).

The above iteration defines a *quasi* Fisher scoring estimation procedure in general, and reduces to exact Fisher scoring for ML estimation when \(c(\theta^{(k)}) = 0_p\), where \(0_p\) is a vector of \(p\) zeros.

For either \(c(\theta) = I_p\) or \(c(\theta) = \left\{i(\theta)\right\}^{-1} j(\theta)\), where \(I_p\) is the \(p \times p\) identity matrix and \(j(\theta)\) is the observed information, \(\theta^{(\infty)}\) (if it exists) is a reduced-bias estimate, in the sense that it corresponds an estimator with bias of smaller asymptotic order than that of the ML estimator (see, Firth 1993; Kosmidis and Firth 2010). The **brglm** estimates correspond to \(c(\theta) = I_p\).

The asymptotic distribution of the reduced-bias estimators is the same to that of the ML estimator (see, Firth 1993 for details). So, the reduced-bias estimates can be readily used to calculate \(z\)-statistics.

For implementing the iteration for bias reduction, we need functions that can compute the gradient of the log-likelihood, the observed and expected information matrix, and \(b(\theta)\) at arbitrary values of \(\theta\).

The **enrichwith** package can produce those functions for any `glm`

object through the `auxiliary_functions`

enrichment option (to see all available enrichment options for `glm`

objects run `get_enrichment_options(modML)`

.

Let’s extract the functions from the `enriched_modML`

object.

```
# Extract the ingredients for the quasi Fisher scoring iteration from the enriched glm object
gradient <- enriched_modML$auxiliary_functions$score # gradient of the log-likelihood
information <- enriched_modML$auxiliary_functions$information # information matrix
bias <- enriched_modML$auxiliary_functions$bias # first-order bias
```

For the more technically minded, note here that the above functions are specific to `modML`

in the sense that they look into a special environment for necessary objects like the model matrix, the model weights, the response vector, and so on.

This stems from the way **enrichwith** has been implemented. In particular, if `create_enrichwith_skeleton`

is used, the user/developer can directly implement enrichment options to enrich objects with functions that directly depend on other components in the object to be enriched.

The following code chunk uses `enriched_modML`

to implement the quasi Fisher scoring procedure for the analysis of the endometrial cancer data. For `p <- length(theta_mle)`

, the starting value for the parameter vector is set to `theta_current <- rep(0, p)`

, and the maximum number of iterations to `maxit <- 100`

. As stopping criterion, we use the absolute change in each parameter value with tolerance `epsilon <- 1e-06`

```
# The quasi Fisher scoring iteration using c(theta) = identity
for (k in seq.int(maxit)) {
s_vector <- gradient(theta_current)
i_matrix <- information(theta_current, type = "expected")
b_vector <- bias(theta_current)
step <- solve(i_matrix) %*% s_vector - b_vector
theta_current <- theta_current + step
# A stopping criterion
if (all(abs(step) < epsilon)) {
break
}
}
(theta_e <- drop(theta_current))
```

```
## (Intercept) NV PI EH
## 1.91460348 1.65892018 -0.01520487 -1.37987837
## attr(,"coefficients")
## [1] 0 0 0 0
## attr(,"dispersion")
## [1] 1
```

The estimation procedure took 8 iterations to converge, and, as expected, the estimates are numerically the same to the ones that **brglm** returned.

`## [1] TRUE`

A set of alternative reduced-bias estimates can be obtained using \(c(\theta) = \left\{i(\theta)\right\}^{-1} j(\theta)\). Starting again at `theta_current <- rep(0, p)`

```
# The quasi Fisher scoring iteration using c(theta) = solve(i(theta)) %*% j(theta)
for (k in seq.int(maxit)) {
s_vector <- gradient(theta_current)
i_matrix <- information(theta_current, type = "expected")
j_matrix <- information(theta_current, type = "observed")
b_vector <- bias(theta_current)
step <- solve(i_matrix) %*% (s_vector - j_matrix %*% b_vector)
theta_current <- theta_current + step
# A stopping criterion
if (all(abs(step) < epsilon)) {
break
}
}
(theta_o <- drop(theta_current))
```

```
## (Intercept) NV PI EH
## 1.89707065 1.72815655 -0.01471219 -1.37254188
```

The estimation procedure took 9 iterations to converge.

The ML estimates and the estimates from the two variants of the bias reduction method are

```
## theta_mle theta_e theta_o
## (Intercept) 2.181 1.915 1.897
## NV 5.805 1.659 1.728
## PI -0.019 -0.015 -0.015
## EH -1.526 -1.380 -1.373
```

Note that the reduced-bias estimates have shrunk towards zero. This is typical for reduced-bias estimation in binomial-response GLMs (see, for example, Cordeiro and McCullagh 1991, Section 8; Kosmidis 2007, Section 5.2, 2014 for shrinkage in cumulative link models).

The corresponding \(z\)-statistics are

```
se_theta_mle <- sqrt(diag(solve(information(theta_mle, type = "expected"))))
se_theta_e <- sqrt(diag(solve(information(theta_e, type = "expected"))))
se_theta_o <- sqrt(diag(solve(information(theta_o, type = "expected"))))
round(data.frame(z_mle = theta_mle/se_theta_mle,
z_br_e = theta_e/se_theta_e,
z_br_o = theta_o/se_theta_o), 3)
```

```
## z_mle z_br_e z_br_o
## (Intercept) 2.544 2.427 2.407
## NV 0.009 2.220 2.215
## PI -0.799 -0.728 -0.701
## EH -3.523 -3.422 -3.411
```

The two variants for bias reduction result in slightly different reduced-bias estimates and \(z\)-statistics, though the \(z\)-statistics from both variants provide some evidence for the existence of an effect for `NV`

.

A general family of bias reduction methods is described in Kosmidis and Firth (2009).

The quasi Fisher scoring iteration that has been described here is at the core of the **brglm2** R package, which provides various bias reduction methods for GLMs.

Agresti, A. 2015. *Foundations of Linear and Generalized Linear Models*. Wiley Series in Probability and Statistics. Wiley.

Cordeiro, G. M., and P. McCullagh. 1991. “Bias Correction in Generalized Linear Models.” *Rssb* 53 (3): 629–43.

Cox, D. R., and E. J. Snell. 1968. “A General Definition of Residuals (with Discussion).” *Journal of the Royal Statistical Society, Series B: Methodological* 30: 248–75.

Firth, D. 1993. “Bias Reduction of Maximum Likelihood Estimates.” *Biometrika* 80 (1): 27–38.

Heinze, G., and M. Schemper. 2002. “A Solution to the Problem of Separation in Logistic Regression.” *Statistics in Medicine* 21: 2409–19.

Kosmidis, I. 2007. “Bias Reduction in Exponential Family Nonlinear Models.” PhD thesis, Department of Statistics, University of Warwick. http://www.ikosmidis.com/files/ikosmidis_thesis.pdf.

———. 2014. “Improved Estimation in Cumulative Link Models.” *Journal of the Royal Statistical Society, Series B: Methodological* 76 (1): 169–96. https://doi.org/10.1111/rssb.12025.

Kosmidis, I., and D. Firth. 2009. “Bias Reduction in Exponential Family Nonlinear Models.” *Biometrika* 96 (4): 793–804. https://doi.org/10.1093/biomet/asp055.

———. 2010. “A Generic Algorithm for Reducing Bias in Parametric Estimation.” *Electronic Journal of Statistics* 4: 1097–1112. https://doi.org/10.1214/10-EJS579.

———. 2011. “Multinomial Logit Bias Reduction via the Poisson Log-Linear Model.” *Biometrika* 98 (3): 755–59.